› 6fgn

Solution NMR

Solution Structure of p300Taz2-p63TA

Released:
DOI: 10.2210/pdb6fgn/pdb
PDB entry 6fgn coloured by chain, ensemble of 20 models, front view.
PDB entry 6fgn coloured by chain, ensemble of 20 models, side view.
PDB entry 6fgn coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.
Krauskopf K, Gebel J, Kazemi S, Tuppi M, Löhr F, Schäfer B, Koch J, Güntert P, Dötsch V, Kehrloesser S
Structure 26 1091-1100.e4 (2018)
PMID: 30099987

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170793 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase p300; Tumor protein 63 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 13.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q09472 (Residues: 1723-1812; Coverage: 4%)
  • Canonical: Q9H3D4 (Residues: 47-73; Coverage: 4%)
Gene names: EP300, KET, P300, P63, P73H, P73L, TP63, TP73L
Sequence domains: TAZ zinc finger

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

DNA Damaged Induced Cell Death in Oocytes.
Gebel et al. (2020)
2 more

2 mentions without citation

Structural diversity of p63 and p73 isoforms.
Osterburg et al. (2022)
1 more