› 6fi0

X-ray diffraction
1.9Å resolution

Crystal structure of BAZ2A PHD zinc finger in complex with Fr 19

Released:
DOI: 10.2210/pdb6fi0/pdb
PDB entry 6fi0 coloured by chain, front view.
PDB entry 6fi0 coloured by chain, side view.
PDB entry 6fi0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach.
Amato A, Lucas X, Bortoluzzi A, Wright D, Ciulli A
ACS Chem Biol 13 915-921 (2018)
PMID: 29529862

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193785 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain adjacent to zinc finger domain protein 2A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 58 amino acids
Theoretical weight: 6.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UIF9 (Residues: 1673-1728; Coverage: 3%)
Gene names: BAZ2A, KIAA0314, TIP5
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

5 bound ligands:
Ligand ZN 8 x ZN
Ligand PO4 4 x PO4
Ligand K 2 x K
Ligand DEW 2 x DEW
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P43212
Unit cell:
a: 72.095Å b: 72.095Å c: 99.198Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Targeting epigenetic protein-protein interactions with small-molecule inhibitors.
Linhares et al. (2020)
2 more

2 mentions without citation

Atypical histone targets of PHD fingers.
Black et al. (2023)
1 more