› 6fic

X-ray diffraction
2.18Å resolution

Bivalent Inhibitor UNC4512 Bound to the TAF1 Bromodomain Tandem

Released:
DOI: 10.2210/pdb6fic/pdb
PDB entry 6fic coloured by chain, front view.
PDB entry 6fic coloured by chain, side view.
PDB entry 6fic coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Mathea S, Suh JL, Salah E, Tallant C, Siejka P, Pike ACW, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, James LI, Frye SV, Knapp S

Function and Biology Details

Reactions catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149352 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription initiation factor TFIID subunit 1 Chain: T
Molecule details ›
Chain: T
Length: 280 amino acids
Theoretical weight: 32.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21675 (Residues: 1380-1659; Coverage: 15%)
Gene names: BA2R, CCG1, CCGS, TAF1, TAF2A
Sequence domains: Bromodomain

Ligands and Environments

1 bound ligand:
Ligand DKH 2 x DKH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P3221
Unit cell:
a: 113.573Å b: 113.573Å c: 72.592Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.201 0.236
Expression system: Escherichia coli

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