› 6fjc

X-ray diffraction
2.6Å resolution

Human KIBRA C2 domain mutant C771A in complex with phosphatidylinositol 3,4,5-trisphosphate

Released:
DOI: 10.2210/pdb6fjc/pdb
PDB entry 6fjc coloured by chain, front view.
PDB entry 6fjc coloured by chain, side view.
PDB entry 6fjc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Distinctive phosphoinositide- and Ca2+-binding properties of normal and cognitive performance-linked variant forms of KIBRA C2 domain.
Posner MG, Upadhyay A, Ishima R, Kalli AC, Harris G, Kremerskothen J, Sansom MSP, Crennell SJ, Bagby S
J Biol Chem 293 9335-9344 (2018)
PMID: 29724824

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein KIBRA Chains: A, B
Molecule details ›
Chains: A, B
Length: 140 amino acids
Theoretical weight: 15.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8IX03 (Residues: 658-785; Coverage: 12%)
Gene names: KIAA0869, KIBRA, WWC1
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

3 bound ligands:
Ligand GOL 15 x GOL
Ligand 4PT 1 x 4PT
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P6122
Unit cell:
a: 83.404Å b: 83.404Å c: 208.254Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.192 0.264
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Computational Modeling of Realistic Cell Membranes.
Marrink et al. (2019)
4 other articles

2 mentions without citation

Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex.
Kukimoto-Niino et al. (2021)
1 more