› 6fof

X-ray diffraction
2.2Å resolution

Crystal structure of a crystallized variant of h-Gal3: Gal-3[NTS/VII-IX]

Released:
DOI: 10.2210/pdb6fof/pdb
PDB entry 6fof coloured by chain, front view.
PDB entry 6fof coloured by chain, side view.
PDB entry 6fof coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallization of a human galectin-3 variant with two ordered segments in the shortened N-terminal tail.
Flores-Ibarra A, Vértesy S, Medrano FJ, Gabius HJ, Romero A
Sci Rep 8 9835 (2018)
PMID: 29959397

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148217 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-3 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 196 amino acids
Theoretical weight: 21.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P17931 (Residues: 2-250; Coverage: 78%)
Gene names: LGALS3, MAC2
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL
Carbohydrate polymer
1 bound ligand:
Ligand SO4 24 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P212121
Unit cell:
a: 93.851Å b: 98.195Å c: 237.814Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.264
Expression system: Escherichia coli

Quick links

Citations

13 review citations

How galectins have become multifunctional proteins.
García Caballero et al. (2020)
12 more

5 mentions without citation

Chitinase-3-like 1 protein complexes modulate macrophage-mediated immune suppression in glioblastoma.
Chen et al. (2021)
4 more