› 6fuf

X-ray diffraction
3.12Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136068 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Rhodopsin Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35.8 KDa
Source organism: Bos taurus
Expression system: Homo sapiens
UniProt:
  • Canonical: P02699 (Residues: 2-317; Coverage: 91%)
Gene name: RHO
Sequence domains:
Structure domains: Rhodopsin 7-helix transmembrane proteins
Guanine nucleotide-binding protein G(o) subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 214 amino acids
Theoretical weight: 24.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09471 (Residues: 18-354; Coverage: 61%)
Gene name: GNAO1
Sequence domains: G-protein alpha subunit

Ligands and Environments

2 bound ligands:
Ligand RET 1 x RET
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P61
Unit cell:
a: 151.359Å b: 151.359Å c: 96.652Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.259 0.257 0.28
Expression systems:
  • Homo sapiens
  • Escherichia coli

Quick links

Citations

7 review citations

An online resource for GPCR structure determination and analysis.
Munk et al. (2019)
6 more

6 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
5 more