› 6fuy

X-ray diffraction
3Å resolution

Crystal structure of human full-length vinculin-T12-A974K (residues 1-1066)

Released:
DOI: 10.2210/pdb6fuy/pdb
PDB entry 6fuy coloured by chain, front view.
PDB entry 6fuy coloured by chain, side view.
PDB entry 6fuy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conformational states during vinculin unlocking differentially regulate focal adhesion properties.
Chorev DS, Volberg T, Livne A, Eisenstein M, Martins B, Kam Z, Jockusch BM, Medalia O, Sharon M, Geiger B
Sci Rep 8 2693 (2018)
PMID: 29426917

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148317 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vinculin Chain: A
Molecule details ›
Chain: A
Length: 1066 amino acids
Theoretical weight: 116.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P18206 (Residues: 1-1134; Coverage: 94%)
Gene name: VCL
Sequence domains: Vinculin family

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P3121
Unit cell:
a: 97.81Å b: 97.81Å c: 233.77Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.267 0.265 0.305
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Cellular Mechanotransduction: From Tension to Function.
Martino et al. (2018)
4 more