› 6g4q

X-ray diffraction
2.59Å resolution

Structure of human ADP-forming succinyl-CoA ligase complex SUCLG1-SUCLA2

Released:
DOI: 10.2210/pdb6g4q/pdb
PDB entry 6g4q coloured by chain, front view.
PDB entry 6g4q coloured by chain, side view.
PDB entry 6g4q coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Bailey HJ, Shrestha L, Rembeza E, Sorrell FJ, Newman J, Strain-Damerell C, Burgess-Brown N, von Delft F, Arrowsmith C, Edwards A, Bountra C, Yue WW

Function and Biology Details

Reactions catalysed: 
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156816 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 32.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53597 (Residues: 42-346; Coverage: 88%)
Gene name: SUCLG1
Sequence domains:
Structure domains:
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial Chain: B
Molecule details ›
Chain: B
Length: 415 amino acids
Theoretical weight: 45.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P2R7 (Residues: 52-463; Coverage: 89%)
Gene name: SUCLA2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand EDO 8 x EDO
1 modified residue:
Ligand NEP 1 x NEP

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3121
Unit cell:
a: 130.2Å b: 130.2Å c: 119.772Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.208 0.254
Expression system: Escherichia coli

Quick links