› 6g7w

X-ray diffraction
1.75Å resolution

Crystal structure of NHL repeat containing domain of human NHLRC2

Released:
DOI: 10.2210/pdb6g7w/pdb
PDB entry 6g7w coloured by chain, front view.
PDB entry 6g7w coloured by chain, side view.
PDB entry 6g7w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease.
Biterova E, Ignatyev A, Uusimaa J, Hinttala R, Ruddock LW
PLoS One 13 e0202391 (2018)
PMID: 30138417

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185464 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NHL repeat-containing protein 2 Chain: A
Molecule details ›
Chain: A
Length: 360 amino acids
Theoretical weight: 39.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NBF2 (Residues: 221-572; Coverage: 49%)
Gene name: NHLRC2
Sequence domains: NHL repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID30B
Spacegroup: P21
Unit cell:
a: 52.631Å b: 46.491Å c: 70.302Å
α: 90° β: 102.9° γ: 90°
R-values:
R R work R free
0.156 0.155 0.189
Expression system: Escherichia coli

Quick links

Citations

9 citation in other articles

FINCA syndrome-Defining neurobehavioral phenotype in survivors into late childhood.
Badura-Stronka et al. (2022)
8 more

1 mention without citation

Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease.
Biterova et al. (2018)