PDB 6g9h structure summary ‹ Protein Data Bank in Europe (PDBe)

Function and Biology Details

Reaction catalysed:

ATP + a protein = ADP + a phosphoprotein

Biochemical function:

protein serine kinase activity

Biological process:

regulation of early endosome to late endosome transport

Cellular component:

ficolin-1-rich granule lumen

Sequence domains:

Structure analysis Details

Assembly composition:

monomeric (preferred)

Assembly name:

Mitogen-activated protein kinase 1 (preferred)

PDBe Complex ID:

PDB-CPX-151230 (preferred)

Entry contents:

1 distinct polypeptide molecule

Macromolecule:

Mitogen-activated protein kinase 1 Chain: A

Molecule details ›

Chain: A
Length: 368 amino acids
Theoretical weight: 42.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:

Canonical: P28482 (Residues: 1-360; Coverage: 100%)

Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

X-ray source: RIGAKU FR-X

Spacegroup: P2₁

Unit cell:

a: 48.914Å b: 70.673Å c: 60.884Å

α: 90° β: 110.31° γ: 90°

R-values:

R R_work R_free

0.164 0.162 0.213

Expression system: Escherichia coli BL21

Protein Data Bank in Europe

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2

Function and Biology Details

Structure analysis Details

Ligands and Environments

Experiments and Validation Details

Quick links

Citations

2 review citations

PDB-REDO

PDBe › 6g9h

Fragment-based discovery of a highly potent, orally bioavailable inhibitor which modulates the phosphorylation and catalytic activity of ERK1/2

Function and Biology Details

Structure analysis Details

Ligands and Environments

Experiments and Validation Details

Quick links

Citations

2 review citations

PDB-REDO