› 6gc1

X-ray diffraction
2.7Å resolution

Crystal structure of Trx-like and NHL repeat containing domains of human NHLRC2

Released:
DOI: 10.2210/pdb6gc1/pdb
PDB entry 6gc1 coloured by chain, front view.
PDB entry 6gc1 coloured by chain, side view.
PDB entry 6gc1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease.
Biterova E, Ignatyev A, Uusimaa J, Hinttala R, Ruddock LW
PLoS One 13 e0202391 (2018)
PMID: 30138417

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185464 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NHL repeat-containing protein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 579 amino acids
Theoretical weight: 63.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NBF2 (Residues: 1-572; Coverage: 79%)
Gene name: NHLRC2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-3
Spacegroup: P21
Unit cell:
a: 103.284Å b: 103.812Å c: 114.978Å
α: 90° β: 100.77° γ: 90°
R-values:
R R work R free
0.248 0.246 0.287
Expression system: Escherichia coli

Quick links

Citations

9 citation in other articles

A Genome-Wide Knockout Screen in Human Macrophages Identified Host Factors Modulating Salmonella Infection.
Yeung et al. (2019)
8 more

3 mentions without citation

Protein Dynamics in F-like Bacterial Conjugation.
Bragagnolo et al. (2020)
2 more