› 6ggs

Electron Microscopy
3.94Å resolution

Structure of RIP2 CARD filament

Released:
DOI: 10.2210/pdb6ggs/pdb
PDB entry 6ggs coloured by chain, front view.
PDB entry 6ggs coloured by chain, side view.
PDB entry 6ggs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
RIP2 filament formation is required for NOD2 dependent NF-κB signalling.
Pellegrini E, Desfosses A, Wallmann A, Schulze WM, Rehbein K, Mas P, Signor L, Gaudon S, Zenkeviciute G, Hons M, Malet H, Gutsche I, Sachse C, Schoehn G, Oschkinat H, Cusack S
Nat Commun 9 4043 (2018)
PMID: 30279485
Related structures: EMD-4399

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128907 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-interacting serine/threonine-protein kinase 2 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 110 amino acids
Theoretical weight: 12.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43353 (Residues: 431-540; Coverage: 20%)
Gene names: CARDIAK, RICK, RIP2, RIPK2, UNQ277/PRO314/PRO34092
Sequence domains: Caspase recruitment domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.94Å
Relevant EMDB volumes: EMD-4399
Expression system: Escherichia coli

Quick links

Citations

12 review citations

NOD1 and NOD2 in inflammatory and infectious diseases.
Trindade et al. (2020)
11 more

2 mentions without citation

Assembly of platforms for signal transduction in the new era: dimerization, helical filament assembly, and beyond.
Ha et al. (2020)
1 more