6gh8

X-ray diffraction
2.44Å resolution

Crystal structure of GP1 domain of Lujo virus in complex with the first CUB domain of neuropilin-2

Released:
Primary publication:
Structural basis for receptor recognition by Lujo virus.
Nat Microbiol 3 1153-1160 (2018)
PMID: 30150732

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-111506 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Glycoprotein Chains: B, D
Molecule details ›
Chains: B, D
Length: 139 amino acids
Theoretical weight: 16.02 KDa
Source organism: Mammarenavirus lujoense
Expression system: Trichoplusia ni
UniProt:
  • Canonical: C5ILC1 (Residues: 74-199; Coverage: 28%)
Sequence domains: Arenavirus glycoprotein
Neuropilin-2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 133 amino acids
Theoretical weight: 14.91 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60462 (Residues: 27-146; Coverage: 13%)
Gene names: NRP2, VEGF165R2
Sequence domains: CUB domain
Structure domains: Spermadhesin, CUB domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21212
Unit cell:
a: 141.808Å b: 59.294Å c: 83.567Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.268 0.266 0.312
Expression system: Trichoplusia ni