› 6giu

X-ray diffraction
1.39Å resolution

Human IMPase with L-690330

Released:
DOI: 10.2210/pdb6giu/pdb
PDB entry 6giu coloured by chain, front view.
PDB entry 6giu coloured by chain, side view.
PDB entry 6giu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Co-crystallization of human inositol monophosphatase with the lithium mimetic L-690,330.
Kraft L, Roe SM, Gill R, Atack JR
Acta Crystallogr D Struct Biol 74 973-978 (2018)
PMID: 30289407

Function and Biology Details

Reactions catalysed: 
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate
Alpha-D-galactose 1-phosphate + H(2)O = D-galactose + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151370 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inositol monophosphatase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 277 amino acids
Theoretical weight: 30.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29218 (Residues: 1-277; Coverage: 100%)
Gene names: IMPA, IMPA1
Sequence domains: Inositol monophosphatase family
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MN 7 x MN
Ligand L69 2 x L69
Ligand GOL 19 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P3221
Unit cell:
a: 85.29Å b: 85.29Å c: 151.51Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.149 0.148 0.167
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase.
Fenn et al. (2020)
1 more