› 6gl3

X-ray diffraction
2.77Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4-kinase beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 386 amino acids
Theoretical weight: 43.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UBF8 (Residues: 317-428, 532-798; Coverage: 46%)
Gene names: PI4KB, PIK4CB
Sequence domains: Phosphatidylinositol 3- and 4-kinase

Ligands and Environments

1 bound ligand:
Ligand EMW 1 x EMW
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 64.468Å b: 69.484Å c: 172.84Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.278 0.276 0.333
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Beyond PI3Ks: targeting phosphoinositide kinases in disease.
Burke et al. (2022)
2 other articles

3 mentions without citation

Advances in chemical proteomic evaluation of lipid kinases-DAG kinases as a case study.
Ware et al. (2021)
2 more