› 6gq7

X-ray diffraction
2.84Å resolution

PI3Kg IN COMPLEX WITH INH

Released:
DOI: 10.2210/pdb6gq7/pdb
PDB entry 6gq7 coloured by chain, front view.
PDB entry 6gq7 coloured by chain, side view.
PDB entry 6gq7 coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Petersen J

Function and Biology Details

Reactions catalysed: 
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155801 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Chain: A
Molecule details ›
Chain: A
Length: 966 amino acids
Theoretical weight: 110.73 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48736 (Residues: 144-1102; Coverage: 87%)
Gene name: PIK3CG
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand DD8 1 x DD8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: C2
Unit cell:
a: 139.59Å b: 67.066Å c: 104.897Å
α: 90° β: 97.28° γ: 90°
R-values:
R R work R free
0.238 0.235 0.296
Expression system: Spodoptera frugiperda

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