› 6gqj

X-ray diffraction
2.33Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145426 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mast/stem cell growth factor receptor Kit Chains: A, B
Molecule details ›
Chains: A, B
Length: 327 amino acids
Theoretical weight: 37.19 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10721 (Residues: 551-759, 760-933; Coverage: 34%)
Gene names: KIT, SCFR
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand F82 2 x F82
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 86.773Å b: 89.436Å c: 90.343Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.181 0.217
Expression system: Escherichia coli

Quick links

Citations

4 review citations

1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.
Bozorov et al. (2019)
3 more

3 mentions without citation

Synthesis, inverse docking-assisted identification and in vitro biological characterization of Flavonol-based analogs of fisetin as c-Kit, CDK2 and mTOR inhibitors against melanoma and non-melanoma skin cancers.
Roy et al. (2021)
2 more