› 6gyr

X-ray diffraction
3.1Å resolution

Transcription factor dimerization activates the p300 acetyltransferase

Released:
DOI: 10.2210/pdb6gyr/pdb
PDB entry 6gyr coloured by chain, front view.
PDB entry 6gyr coloured by chain, side view.
PDB entry 6gyr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Transcription factor dimerization activates the p300 acetyltransferase.
Ortega E, Rengachari S, Ibrahim Z, Hoghoughi N, Gaucher J, Holehouse AS, Khochbin S, Panne D
Nature 562 538-544 (2018)
PMID: 30323286

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170798 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone acetyltransferase p300 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 588 amino acids
Theoretical weight: 68.65 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia
UniProt:
  • Canonical: Q09472 (Residues: 1046-1664; Coverage: 24%)
Gene names: EP300, P300
Sequence domains:

Ligands and Environments


Cofactor: Ligand 01K 4 x 01K
1 bound ligand:
Ligand ZN 14 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 100.826Å b: 146.717Å c: 116.477Å
α: 90° β: 91.75° γ: 90°
R-values:
R R work R free
0.211 0.209 0.265
Expression system: Trichoplusia

Quick links

Citations

22 review citations

Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate.
Arnold et al. (2019)
21 more

3 mentions without citation

Regulation of Thermogenic Adipocyte Differentiation and Adaptive Thermogenesis Through Histone Acetylation.
Ong et al. (2020)
2 more