› 6gzd

X-ray diffraction
2.28Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155794 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform alpha Chain: A
Molecule details ›
Chain: A
Length: 374 amino acids
Theoretical weight: 43.08 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48729 (Residues: 1-337; Coverage: 100%)
Gene name: CSNK1A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

6 bound ligands:
Ligand DMS 2 x DMS
Ligand PGE 3 x PGE
Ligand EDO 5 x EDO
Ligand PEG 6 x PEG
Ligand TCE 1 x TCE
Ligand LCI 1 x LCI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE MASSIF-1
Spacegroup: I41
Unit cell:
a: 113.383Å b: 113.383Å c: 80.878Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.221
Expression system: Spodoptera frugiperda

Quick links

Citations

26 review citations

Super-enhancers: critical roles and therapeutic targets in hematologic malignancies.
Jia et al. (2019)
25 more

10 mentions without citation

Targeting Casein Kinase 1 (CK1) in Hematological Cancers.
Janovská et al. (2020)
9 more