› 6h06

X-ray diffraction
2.63Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210481 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HUMAN FAB ANTIBODY FRAGMENT OF CBTAU-22.1 Chains: A, C, E, H
Molecule details ›
Chains: A, C, E, H
Length: 224 amino acids
Theoretical weight: 23.87 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
HUMAN FAB ANTIBODY FRAGMENT OF HCBTAU-22.1 Chains: B, D, F, L
Molecule details ›
Chains: B, D, F, L
Length: 219 amino acids
Theoretical weight: 24.09 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Microtubule-associated protein tau Chains: G, I, J, K
Molecule details ›
Chains: G, I, J, K
Length: 26 amino acids
Theoretical weight: 2.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 721-746; Coverage: 3%)
Gene names: MAPT, MAPTL, MTBT1, TAU

Ligands and Environments

1 bound ligand:
Ligand GOL 5 x GOL
3 modified residues:
Ligand PCA 4 x PCA
Ligand TPO 4 x TPO
Ligand SEP 4 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 108.055Å b: 96.209Å c: 108.984Å
α: 90° β: 112.81° γ: 90°
R-values:
R R work R free
0.217 0.216 0.27
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

3 review citations

Immunotherapies for Neurodegenerative Diseases.
Mortada et al. (2021)
2 more

3 mentions without citation

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status.
Pinzi et al. (2023)
2 more