› 6i3i

X-ray diffraction
2.97Å resolution

Crystal structure of reactive center loop (RCL) cleaved angiotensinogen

Released:
DOI: 10.2210/pdb6i3i/pdb
PDB entry 6i3i coloured by chain, front view.
PDB entry 6i3i coloured by chain, side view.
PDB entry 6i3i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
Yan Y, Zhou A, Carrell RW, Read RJ
J Biol Chem 294 2353-2364 (2019)
PMID: 30563843

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133805 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiotensinogen Chain: A
Molecule details ›
Chain: A
Length: 458 amino acids
Theoretical weight: 50.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01019 (Residues: 25-476; Coverage: 100%)
Gene names: AGT, SERPINA8
Sequence domains: Serpin (serine protease inhibitor)

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P41
Unit cell:
a: 80.14Å b: 80.14Å c: 117.13Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.218 0.237
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Angiotensinogen and the Modulation of Blood Pressure.
Shu et al. (2021)
3 more

1 mention without citation

Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
Yan et al. (2019)