› 6mal

X-ray diffraction
2.6Å resolution

Structure of human Nocturnin C-terminal domain

Released:
DOI: 10.2210/pdb6mal/pdb
PDB entry 6mal coloured by chain, front view.
PDB entry 6mal coloured by chain, side view.
PDB entry 6mal coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of Human Nocturnin Catalytic Domain.
Estrella MA, Du J, Korennykh A
Sci Rep 8 16294 (2018)
PMID: 30389976

Function and Biology Details

Reaction catalysed: 
NADP(+) + H(2)O = NAD(+) + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193834 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nocturnin Chain: A
Molecule details ›
Chain: A
Length: 312 amino acids
Theoretical weight: 35.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UK39 (Residues: 122-431; Coverage: 72%)
Gene names: CCR4, CCRN4L, NOC, NOCT
Sequence domains: Endonuclease/Exonuclease/phosphatase family

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P41212
Unit cell:
a: 61.4Å b: 61.4Å c: 155.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.255 0.252 0.307
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

How RNases Shape Mitochondrial Transcriptomes.
Cartalas et al. (2022)
6 other articles

3 mentions without citation

The metabolites NADP+ and NADPH are the targets of the circadian protein Nocturnin (Curled).
Estrella et al. (2019)
2 more