› 6mce

Solution NMR

Solution structure of HIV-1 TAR with Tat RNA Binding Domain

Released:
DOI: 10.2210/pdb6mce/pdb
PDB entry 6mce coloured by chain, ensemble of 10 models, front view.
PDB entry 6mce coloured by chain, ensemble of 10 models, side view.
PDB entry 6mce coloured by chain, ensemble of 10 models, top view.
Source organisms:
Primary publication:
HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry.
Pham VV, Salguero C, Khan SN, Meagher JL, Brown WC, Humbert N, de Rocquigny H, Smith JL, D'Souza VM
Nat Commun 9 4266 (2018)
PMID: 30323330

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138047 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Protein Tat Chain: B
Molecule details ›
Chain: B
Length: 17 amino acids
Theoretical weight: 2.16 KDa
Source organism: HIV-1 M:B_HXB2R
Expression system: Not provided
UniProt:
  • Canonical: P04608 (Residues: 44-60; Coverage: 20%)
Gene name: tat
TAR RNA Chain: A
Molecule details ›
Chain: A
Length: 30 nucleotides
Theoretical weight: 9.65 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 51%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

8 review citations

Unraveling the structure and biological functions of RNA triple helices.
Brown JA. (2020)
7 more

7 mentions without citation

Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery.
Chavali et al. (2019)
6 more