› 6mff

X-ray diffraction
2.6Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127609 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HLA class II histocompatibility antigen, DQ alpha 1 chain Chain: A
Molecule details ›
Chain: A
Length: 190 amino acids
Theoretical weight: 21.42 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01909 (Residues: 24-206; Coverage: 79%)
Gene name: HLA-DQA1
Sequence domains:
Structure domains:
Ig-like domain-containing protein Chain: C
Molecule details ›
Chain: C
Length: 226 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O19712 (Residues: 1-192; Coverage: 84%)
Gene name: HLA-DQB1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: C2221
Unit cell:
a: 93.87Å b: 96.61Å c: 107.05Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.25
Expression system: Trichoplusia ni

Quick links

Citations

5 review citations

An Interpretable Classification Model Using Gluten-Specific TCR Sequences Shows Diagnostic Potential in Coeliac Disease.
Fowler et al. (2023)
4 more

3 mentions without citation

Structural Perspective of Gliadin Peptides Active in Celiac Disease.
Falcigno et al. (2020)
2 more