› 6mfg

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127613 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HLA class II histocompatibility antigen, DQ alpha 1 chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 190 amino acids
Theoretical weight: 21.42 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01909 (Residues: 24-206; Coverage: 79%)
Gene name: HLA-DQA1
Sequence domains:
Structure domains:
Ig-like domain-containing protein Chains: E, F
Molecule details ›
Chains: E, F
Length: 226 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O19712 (Residues: 1-192; Coverage: 84%)
Gene name: HLA-DQB1
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 59.226Å b: 101.968Å c: 70.528Å
α: 90° β: 91.78° γ: 90°
R-values:
R R work R free
0.188 0.187 0.222
Expression system: Trichoplusia ni

Quick links

Citations

5 review citations

An Interpretable Classification Model Using Gluten-Specific TCR Sequences Shows Diagnostic Potential in Coeliac Disease.
Fowler et al. (2023)
4 more

6 mentions without citation

A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation.
Frick et al. (2021)
5 more