› 6mgp

X-ray diffraction
2.13Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154372 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Tumor necrosis factor ligand superfamily member 9 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 207 amino acids
Theoretical weight: 21.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P41273 (Residues: 58-254; Coverage: 78%)
Gene name: TNFSF9
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 9 Chains: X, Y, Z
Molecule details ›
Chains: X, Y, Z
Length: 144 amino acids
Theoretical weight: 15.67 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q07011 (Residues: 25-162; Coverage: 60%)
Gene names: CD137, ILA, TNFRSF9
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer
2 bound ligands:
Ligand ACT 5 x ACT
Ligand GOL 4 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: C2221
Unit cell:
a: 102.013Å b: 229.378Å c: 114.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.25
Expression system: Trichoplusia ni

Quick links

Citations

17 review citations

CD137 as an Attractive T Cell Co-Stimulatory Target in the TNFRSF for Immuno-Oncology Drug Development.
Hashimoto K. (2021)
16 more

7 mentions without citation

Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab.
Chin et al. (2018)
6 more