6mhr

X-ray diffraction
2.8Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211941 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Urelumab Fab heavy chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 235 amino acids
Theoretical weight: 25.39 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Urelumab Fab kappa chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 216 amino acids
Theoretical weight: 23.52 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Tumor necrosis factor receptor superfamily member 9 Chains: C, F
Molecule details ›
Chains: C, F
Length: 144 amino acids
Theoretical weight: 15.67 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q07011 (Residues: 25-162; Coverage: 60%)
Gene names: CD137, ILA, TNFRSF9
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, FUC
Carbohydrate polymer : NEW Components: NAG, FUC
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2221
Unit cell:
a: 77.148Å b: 192.058Å c: 344.581Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.2 0.2 0.222
Expression systems:
  • Homo sapiens
  • Trichoplusia ni