› 6mj7

X-ray diffraction
1.41Å resolution

Crystal structure of p62 ZZ domain in complex with free arginine

Released:
DOI: 10.2210/pdb6mj7/pdb
PDB entry 6mj7 coloured by chain, front view.
PDB entry 6mj7 coloured by chain, side view.
PDB entry 6mj7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
ZZ-dependent regulation of p62/SQSTM1 in autophagy.
Zhang Y, Mun SR, Linares JF, Ahn J, Towers CG, Ji CH, Fitzwalter BE, Holden MR, Mi W, Shi X, Moscat J, Thorburn A, Diaz-Meco MT, Kwon YT, Kutateladze TG
Nat Commun 9 4373 (2018)
PMID: 30349045

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sequestosome-1 Chain: A
Molecule details ›
Chain: A
Length: 55 amino acids
Theoretical weight: 5.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13501 (Residues: 120-171; Coverage: 12%)
Gene names: ORCA, OSIL, SQSTM1
Sequence domains: Zinc finger, ZZ type

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand DIO 1 x DIO
Ligand ARG 1 x ARG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: C2
Unit cell:
a: 44.971Å b: 32.269Å c: 34.941Å
α: 90° β: 122.16° γ: 90°
R-values:
R R work R free
0.139 0.136 0.165
Expression system: Escherichia coli

Quick links

Citations

18 review citations

History of the Selective Autophagy Research: How Did It Begin and Where Does It Stand Today?
Kirkin V. (2020)
17 more

1 mention without citation

[Cytotoxicity and underlying mechanism of evodiamine in HepG2 cells].
Gao et al. (2021)