› 6n8g

X-ray diffraction
2Å resolution

IRAK4 bound to benzoxazole compound

Released:
DOI: 10.2210/pdb6n8g/pdb
PDB entry 6n8g coloured by chain, front view.
PDB entry 6n8g coloured by chain, side view.
PDB entry 6n8g coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Larsen NA, Bloudoff K, Subramanian V, Dobrzanska M, Gluza K

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 297 amino acids
Theoretical weight: 33.55 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9NWZ3 (Residues: 164-460; Coverage: 65%)
Gene name: IRAK4
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

1 bound ligand:
Ligand KFD 4 x KFD
2 modified residues:
Ligand TPO 8 x TPO
Ligand SEP 4 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2
Unit cell:
a: 142.955Å b: 141.927Å c: 88.095Å
α: 90° β: 124.58° γ: 90°
R-values:
R R work R free
0.177 0.174 0.22
Expression system: Spodoptera frugiperda

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