› 6q21

X-ray diffraction
1.95Å resolution

MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS

Released:
DOI: 10.2210/pdb6q21/pdb
PDB entry 6q21 coloured by chain, front view.
PDB entry 6q21 coloured by chain, side view.
PDB entry 6q21 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins.
Milburn MV, Tong L, deVos AM, Brünger A, Yamaizumi Z, Nishimura S, Kim SH
Science 247 939-45 (1990)
PMID: 2406906

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133982 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase HRas Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 171 amino acids
Theoretical weight: 19.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01112 (Residues: 1-171; Coverage: 91%)
Gene names: HRAS, HRAS1
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 4 x MG
Ligand GCP 4 x GCP
No modified residues

Experiments and Validation Details

Entry percentile scores
Unit cell:
a: 41.98Å b: 79.12Å c: 128.5Å
α: 90° β: 90° γ: 117.48°
R-values:
R R work R free
0.19 0.19 not available
Expression system: Not provided

Quick links

Citations

134 review citations

The GTPase superfamily: conserved structure and molecular mechanism.
Bourne et al. (1991)
133 more

188 mentions without citation

The SET-domain protein superfamily: protein lysine methyltransferases.
Dillon et al. (2005)
187 more