› 6a32

X-ray diffraction
1.87Å resolution

Crystal structure of PDGFRA kinase domain mutant T674I

Released:
DOI: 10.2210/pdb6a32/pdb
PDB entry 6a32 coloured by chain, front view.
PDB entry 6a32 coloured by chain, side view.
PDB entry 6a32 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yan XE, Liang L, Yun CH

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147663 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Platelet-derived growth factor receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 356 amino acids
Theoretical weight: 40.6 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P16234 (Residues: 550-973; Coverage: 33%)
Gene names: PDGFR2, PDGFRA, RHEPDGFRA
Sequence domains: Protein tyrosine and serine/threonine kinase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 37.194Å b: 87.604Å c: 96.332Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.24
Expression system: Spodoptera frugiperda

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