Function and Biology Details
Reaction catalysed:
Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Peptidase M2, peptidyl-dipeptidase A
- Spike glycoprotein S2 superfamily, coronavirus
- Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
- Spike glycoprotein S1, N-terminal domain, betacoronavirus-like
- Spike glycoprotein S2, coronavirus, heptad repeat 2
- Spike glycoprotein S2, coronavirus, heptad repeat 1
- Spike glycoprotein S2, coronavirus
- Coronavirus spike glycoprotein S1, C-terminal
5 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157814 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Spike glycoprotein
Molecule details ›
Chains: A, B, C
Length: 1203 amino acids
Theoretical weight: 133.76 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 1203 amino acids
Theoretical weight: 133.76 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P59594 (Residues: 1-1196; Coverage: 95%)
Sequence domains:
Processed angiotensin-converting enzyme 2
Molecule details ›
Chain: D
Length: 603 amino acids
Theoretical weight: 69.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Angiotensin-converting enzyme
Length: 603 amino acids
Theoretical weight: 69.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical: Q9BYF1 (Residues: 19-615; Coverage: 76%)
Sequence domains: Angiotensin-converting enzyme
