› 6acn

X-ray diffraction
2.5Å resolution

STRUCTURE OF ACTIVATED ACONITASE. FORMATION OF THE (4FE-4S) CLUSTER IN THE CRYSTAL

Released:
DOI: 10.2210/pdb6acn/pdb
PDB entry 6acn coloured by chain, front view.
PDB entry 6acn coloured by chain, side view.
PDB entry 6acn coloured by chain, top view.
Source organism: Sus scrofa
Primary publication:
Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal.
Robbins AH, Stout CD
Proc Natl Acad Sci U S A 86 3639-43 (1989)
PMID: 2726740

Function and Biology Details

Reaction catalysed: 
(1a) citrate = cis-aconitate + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147667 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aconitate hydratase, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 754 amino acids
Theoretical weight: 82.79 KDa
Source organism: Sus scrofa
Expression system: Not provided
UniProt:
  • Canonical: P16276 (Residues: 28-781; Coverage: 97%)
Gene name: ACO2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 1 x SO4
Ligand SF4 1 x SF4
Ligand TRC 1 x TRC
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 173.6Å b: 72Å c: 72.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 not available
Expression system: Not provided

Quick links

Citations

14 review citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.
Hentze et al. (1996)
13 more

4 mentions without citation

LIGSITEcsc: predicting ligand binding sites using the Connolly surface and degree of conservation.
Huang et al. (2006)
3 more