› 6ae3

X-ray diffraction
2.14Å resolution

Crystal structure of GSK3beta complexed with Morin

Released:
DOI: 10.2210/pdb6ae3/pdb
PDB entry 6ae3 coloured by chain, front view.
PDB entry 6ae3 coloured by chain, side view.
PDB entry 6ae3 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of GSK3β in complex with the flavonoid, morin.
Kim K, Cha JS, Kim JS, Ahn J, Ha NC, Cho HS
Biochem Biophys Res Commun 504 519-524 (2018)
PMID: 30197003

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194399 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycogen synthase kinase-3 beta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 420 amino acids
Theoretical weight: 46.85 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9WV60 (Residues: 1-420; Coverage: 100%)
Gene name: Gsk3b
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MRI 2 x MRI
Ligand GOL 4 x GOL
1 modified residue:
Ligand PTR 4 x PTR

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P21
Unit cell:
a: 67.588Å b: 134.36Å c: 100.393Å
α: 90° β: 103.8° γ: 90°
R-values:
R R work R free
0.192 0.191 0.226
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Flavonoids as an Intervention for Alzheimer's Disease: Progress and Hurdles Towards Defining a Mechanism of Action.
Hole et al. (2021)
1 more

4 mentions without citation

Molecular Mechanism of the Effect of Huanglian Jiedu Decoction on Type 2 Diabetes Mellitus Based on Network Pharmacology and Molecular Docking.
Yin et al. (2020)
3 more