› 6apj

X-ray diffraction
3.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193800 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 374 amino acids
Theoretical weight: 42.22 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UJ37 (Residues: 1-374; Coverage: 100%)
Gene names: SIAT7B, SIATL1, ST6GALNAC2, STHM
Sequence domains: Glycosyltransferase family 29 (sialyltransferase)

Ligands and Environments

1 bound ligand:
Ligand NAG 4 x NAG
1 modified residue:
Ligand MSE 30 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P1
Unit cell:
a: 71.346Å b: 71.803Å c: 134.246Å
α: 98.78° β: 101.92° γ: 103.48°
R-values:
R R work R free
0.206 0.201 0.252
Expression system: Homo sapiens

Quick links

Citations

19 review citations

A perspective on the PDB's impact on the field of glycobiology.
Prestegard JH. (2021)
18 more

1 mention without citation

The vertebrate sialylation machinery: structure-function and molecular evolution of GT-29 sialyltransferases.
Harduin-Lepers A. (2023)