› 6at5

X-ray diffraction
1.5Å resolution

Crystal structure of HLA-B*07:02 in complex with an NY-ESO-1 peptide

Released:
DOI: 10.2210/pdb6at5/pdb
PDB entry 6at5 coloured by chain, front view.
PDB entry 6at5 coloured by chain, side view.
PDB entry 6at5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide.
Chan KF, Gully BS, Gras S, Beringer DX, Kjer-Nielsen L, Cebon J, McCluskey J, Chen W, Rossjohn J
Nat Commun 9 1026 (2018)
PMID: 29531227

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135172 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 40.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01889 (Residues: 1-362; Coverage: 100%)
Gene names: HLA-B, HLAB
Sequence domains:
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 119 amino acids
Theoretical weight: 13.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 1-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
Cancer/testis antigen 1 Chain: C
Molecule details ›
Chain: C
Length: 13 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P78358 (Residues: 60-72; Coverage: 7%)
Gene names: CTAG, CTAG1, CTAG1A, CTAG1B, ESO1, LAGE2, LAGE2A, LAGE2B

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 50.194Å b: 82.066Å c: 112.047Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.211 0.23
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

4 review citations

γδ T Cells in the Tumor Microenvironment-Interactions With Other Immune Cells.
Chan et al. (2022)
3 more

7 mentions without citation

Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide.
Chan et al. (2018)
6 more