6au8

X-ray diffraction
1.8Å resolution

1.8 angstrom crystal structure of the human Bag6-NLS & TRC35 complex

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for regulation of the nucleo-cytoplasmic distribution of Bag6 by TRC35.
Proc Natl Acad Sci U S A 114 11679-11684 (2017)
PMID: 29042515

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-155462 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Golgi to ER traffic protein 4 homolog Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 32.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7L5D6 (Residues: 23-305; Coverage: 87%)
Gene names: C7orf20, CEE, CGI-20, GET4, TRC35
Sequence domains: Golgi to ER traffic protein 4
Large proline-rich protein BAG6 Chain: C
Molecule details ›
Chain: C
Length: 43 amino acids
Theoretical weight: 4.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46379 (Residues: 1008-1050; Coverage: 4%)
Gene names: BAG6, BAT3, G3

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: P212121
Unit cell:
a: 41.66Å b: 84.56Å c: 102.58Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.159 0.202
Expression system: Escherichia coli