› 6b57

X-ray diffraction
1.93Å resolution

tudor in complex with ligand

Released:
DOI: 10.2210/pdb6b57/pdb
PDB entry 6b57 coloured by chain, front view.
PDB entry 6b57 coloured by chain, side view.
PDB entry 6b57 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.
Zhang H, Liu K, Izumi N, Huang H, Ding D, Ni Z, Sidhu SS, Chen C, Tomari Y, Min J
Proc Natl Acad Sci U S A 114 12483-12488 (2017)
PMID: 29118143

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195169 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tudor and KH domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 231 amino acids
Theoretical weight: 25.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y2W6 (Residues: 309-497; Coverage: 34%)
Gene names: TDRD2, TDRKH
Sequence domains: Tudor domain

Ligands and Environments

1 bound ligand:
Ligand UNX 34 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 47.07Å b: 72.66Å c: 130.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.234
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.
St George-Hyslop et al. (2018)
2 more

3 mentions without citation

A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans.
Manage et al. (2020)
2 more