6b5b

Electron Microscopy
5.2Å resolution

Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-174853 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Baculoviral IAP repeat-containing protein 1e Chain: A
Molecule details ›
Chain: A
Length: 1403 amino acids
Theoretical weight: 159.87 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9R016 (Residues: 1-1403; Coverage: 100%)
Gene names: Birc1e, Naip-rs3, Naip5
Sequence domains:
NLR family CARD domain-containing protein 4 Chains: B, C
Molecule details ›
Chains: B, C
Length: 1024 amino acids
Theoretical weight: 116.89 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q3UP24 (Residues: 1-1024; Coverage: 100%)
Gene names: Card12, Ipaf, Nlrc4
Sequence domains:
Flagellin Chain: F
Molecule details ›
Chain: F
Length: 566 amino acids
Theoretical weight: 58.49 KDa
Source organism: Legionella pneumophila
Expression system: Homo sapiens
UniProt:
  • Canonical: Q5ZVV0 (Residues: 2-475; Coverage: 100%)
Gene names: fliC, lpg1340
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 5.2Å
Relevant EMDB volumes: EMD-7055
Expression system: Homo sapiens