› 6b7h

X-ray diffraction
2.82Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172107 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Metabotropic glutamate receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 517 amino acids
Theoretical weight: 58.78 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q14832 (Residues: 2-507; Coverage: 57%)
Gene names: GPRC1C, GRM3, MGLUR3
Sequence domains: Receptor family ligand binding region

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
3 bound ligands:
Ligand NAG 1 x NAG
Ligand CWY 1 x CWY
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P3221
Unit cell:
a: 80.081Å b: 80.081Å c: 161.887Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.184 0.223
Expression system: unidentified baculovirus

Quick links

Citations

5 review citations

Allosteric Molecular Switches in Metabotropic Glutamate Receptors.
Orgován et al. (2021)
4 more

1 mention without citation

Insights about multi-targeting and synergistic neuromodulators in Ayurvedic herbs against epilepsy: integrated computational studies on drug-target and protein-protein interaction networks.
Choudhary et al. (2019)