› 6b8o

X-ray diffraction
2.2Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192737 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triggering receptor expressed on myeloid cells 2 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 169 amino acids
Theoretical weight: 19.14 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9NZC2 (Residues: 19-174; Coverage: 74%)
Gene name: TREM2
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

5 bound ligands:
Ligand NAG 6 x NAG
Ligand IOD 7 x IOD
Ligand SO4 11 x SO4
Ligand EDO 10 x EDO
Ligand PSF 3 x PSF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P41212
Unit cell:
a: 160.331Å b: 160.331Å c: 86.205Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.222 0.261
Expression system: Homo sapiens

Quick links

Citations

20 review citations

TREM2 - a key player in microglial biology and Alzheimer disease.
Ulland et al. (2018)
19 more

6 mentions without citation

TREM2 dependent and independent functions of microglia in Alzheimer's disease.
Hou et al. (2022)
5 more