› 6bo5

Electron Microscopy
3.6Å resolution

TRPV2 ion channel in partially closed state

Released:
DOI: 10.2210/pdb6bo5/pdb
PDB entry 6bo5 coloured by chain, front view.
PDB entry 6bo5 coloured by chain, side view.
PDB entry 6bo5 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structures of TRPV2 in distinct conformations provide insight into role of the pore turret.
Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG
Nat Struct Mol Biol 26 40-49 (2019)
PMID: 30598551
Related structures: EMD-7119

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 695 amino acids
Theoretical weight: 79.48 KDa
Source organism: Rattus norvegicus
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: Q9WUD2 (Residues: 72-726; Coverage: 86%)
Gene names: Sac2b, Trpv2, Vrl1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-7119
Expression system: Saccharomyces cerevisiae

Quick links

Citations

8 review citations

Structural mechanisms of transient receptor potential ion channels.
Cao E. (2020)
7 more

5 mentions without citation

Structural insights into the gating mechanisms of TRPV channels.
Pumroy et al. (2020)
4 more