› 6bqr

Electron Microscopy
3.2Å resolution

Human TRPM4 ion channel in lipid nanodiscs in a calcium-free state

Released:
DOI: 10.2210/pdb6bqr/pdb
PDB entry 6bqr coloured by chain, front view.
PDB entry 6bqr coloured by chain, side view.
PDB entry 6bqr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the human TRPM4 ion channel in a lipid nanodisc.
Autzen HE, Myasnikov AG, Campbell MG, Asarnow D, Julius D, Cheng Y
Science 359 228-232 (2018)
PMID: 29217581
Related structures: EMD-7132

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 1094 amino acids
Theoretical weight: 121.48 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8TD43 (Residues: 75-1168; Coverage: 90%)
Gene names: LTRPC4, TRPM4
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand Y01 12 x Y01
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-7132
Expression system: Homo sapiens

Quick links

Citations

42 review citations

Dawning of a new era in TRP channel structural biology by cryo-electron microscopy.
Madej et al. (2018)
41 more

11 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
10 more