› 6bsl

X-ray diffraction
1.45Å resolution

BMP1 complexed with a reverse hydroxymate - compound 22

Released:
DOI: 10.2210/pdb6bsl/pdb
PDB entry 6bsl coloured by chain, front view.
PDB entry 6bsl coloured by chain, side view.
PDB entry 6bsl coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
Kallander LS, Washburn D, Hilfiker MA, Eidam HS, Lawhorn BG, Prendergast J, Fox R, Dowdell S, Manns S, Hoang T, Zhao S, Ye G, Hammond M, Holt DA, Roethke T, Hong X, Reid RA, Gampe R, Zhang H, Diaz E, Rendina AR, Quinn AM, Willette B
ACS Med Chem Lett 9 736-740 (2018)
PMID: 30034610

Function and Biology Details

Reaction catalysed: 
Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146609 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone morphogenetic protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 202 amino acids
Theoretical weight: 23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13497 (Residues: 121-321; Coverage: 21%)
Gene names: BMP1, PCOLC
Sequence domains: Astacin (Peptidase family M12A)
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

4 bound ligands:
Ligand SCN 2 x SCN
Ligand ZN 3 x ZN
Ligand EVV 1 x EVV
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 90.554Å b: 124.441Å c: 43.639Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.209
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

BMP1 is not required for lung fibrosis in mice.
Ma et al. (2022)
1 more

3 mentions without citation

Procollagen C-proteinase enhancer-1 (PCPE-1), a potential biomarker and therapeutic target for fibrosis.
Lagoutte et al. (2021)
2 more