› 6bsm

X-ray diffraction
2.33Å resolution

BMP1 complexed with a reverse hydroxamate - compound 4

Released:
DOI: 10.2210/pdb6bsm/pdb
PDB entry 6bsm coloured by chain, front view.
PDB entry 6bsm coloured by chain, side view.
PDB entry 6bsm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
Kallander LS, Washburn D, Hilfiker MA, Eidam HS, Lawhorn BG, Prendergast J, Fox R, Dowdell S, Manns S, Hoang T, Zhao S, Ye G, Hammond M, Holt DA, Roethke T, Hong X, Reid RA, Gampe R, Zhang H, Diaz E, Rendina AR, Quinn AM, Willette B
ACS Med Chem Lett 9 736-740 (2018)
PMID: 30034610

Function and Biology Details

Reaction catalysed: 
Cleavage of the C-terminal propeptide at Ala-|-Asp in type I and II procollagens and at Arg-|-Asp in type III.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146609 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone morphogenetic protein 1 Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13497 (Residues: 121-320; Coverage: 21%)
Gene names: BMP1, PCOLC
Sequence domains: Astacin (Peptidase family M12A)
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand E7D 1 x E7D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P213
Unit cell:
a: 101.789Å b: 101.789Å c: 101.789Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.192 0.224
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

BMP1 is not required for lung fibrosis in mice.
Ma et al. (2022)
1 more

2 mentions without citation

Dynamics of the secreted frizzled related protein Sizzled and potential implications for binding to bone morphogenetic protein-1 (BMP-1).
Sharma et al. (2022)
1 more