› 6btk

X-ray diffraction
1.1Å resolution

Segment from bank vole prion protein 168-176 QYNNQNNFV

Released:
DOI: 10.2210/pdb6btk/pdb
PDB entry 6btk coloured by chain, front view.
PDB entry 6btk coloured by chain, side view.
PDB entry 6btk coloured by chain, top view.
Source organism: Myodes glareolus
Primary publication:
Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.
Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA
Nat Struct Mol Biol 25 131-134 (2018)
PMID: 29335561

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo decamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major prion protein Chain: A
Molecule details ›
Chain: A
Length: 9 amino acids
Theoretical weight: 1.14 KDa
Source organism: Myodes glareolus
Expression system: Not provided
UniProt:
  • Canonical: Q8VHV5 (Residues: 168-176; Coverage: 4%)
Gene name: PrP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P1
Unit cell:
a: 4.874Å b: 10.107Å c: 30.415Å
α: 93.36° β: 91.15° γ: 101.66°
R-values:
R R work R free
0.141 0.139 0.162
Expression system: Not provided

Quick links

Citations

17 review citations

3D Electron Diffraction: The Nanocrystallography Revolution.
Gemmi et al. (2019)
16 more

2 mentions without citation

Atomistic fibrillar architectures of polar prion-inspired heptapeptides.
Peccati et al. (2020)
1 more