› 6bwi

Electron Microscopy
3.7Å resolution

3.7 angstrom cryoEM structure of full length human TRPM4

Released:
DOI: 10.2210/pdb6bwi/pdb
PDB entry 6bwi coloured by chain, front view.
PDB entry 6bwi coloured by chain, side view.
PDB entry 6bwi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of full-length human TRPM4.
Duan J, Li Z, Li J, Santa-Cruz A, Sanchez-Martinez S, Zhang J, Clapham DE
Proc Natl Acad Sci U S A 115 2377-2382 (2018)
PMID: 29463718
Related structures: EMD-7299

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily M member 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 977 amino acids
Theoretical weight: 104.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8TD43 (Residues: 395-1176; Coverage: 64%)
Gene names: LTRPC4, TRPM4
Sequence domains: Ion transport protein

Ligands and Environments

3 bound ligands:
Ligand NA 5 x NA
Ligand Y01 24 x Y01
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.7Å
Relevant EMDB volumes: EMD-7299
Expression system: Spodoptera frugiperda

Quick links

Citations

18 review citations

TRPM Channels in Human Diseases.
Jimenez et al. (2020)
17 more

7 mentions without citation

A structural overview of the ion channels of the TRPM family.
Huang et al. (2020)
6 more