6bwv

X-ray diffraction
2.4Å resolution

Crystal Structure of the 4-1BB/4-1BBL Complex

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human 4-1BB/4-1BBL complex.
J Biol Chem 293 9880-9891 (2018)
PMID: 29720399

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-154372 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 9 Chains: A, B
Molecule details ›
Chains: A, B
Length: 156 amino acids
Theoretical weight: 16.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41273 (Residues: 89-242; Coverage: 61%)
Gene name: TNFSF9
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 9 Chains: D, E
Molecule details ›
Chains: D, E
Length: 141 amino acids
Theoretical weight: 15.12 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q07011 (Residues: 24-160; Coverage: 59%)
Gene names: CD137, ILA, TNFRSF9
Sequence domains: TNFR/NGFR cysteine-rich region

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Spacegroup: I213
Unit cell:
a: 161.571Å b: 161.571Å c: 161.571Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.227 0.265
Expression systems:
  • Escherichia coli
  • Homo sapiens