› 6bzr

X-ray diffraction
2.8Å resolution

Human ABCC6 NBD2 in ADP-bound state

Released:
DOI: 10.2210/pdb6bzr/pdb
PDB entry 6bzr coloured by chain, front view.
PDB entry 6bzr coloured by chain, side view.
PDB entry 6bzr coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zheng A, Thibodeau PH

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131867 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family C member 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 251 amino acids
Theoretical weight: 27.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95255 (Residues: 1254-1503; Coverage: 17%)
Gene names: ABCC6, ARA, MRP6
Sequence domains: ABC transporter

Ligands and Environments

2 bound ligands:
Ligand ADP 2 x ADP
Ligand CIT 2 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 55.76Å b: 93.12Å c: 64.17Å
α: 90° β: 112.497° γ: 90°
R-values:
R R work R free
0.234 0.231 0.264
Expression system: Escherichia coli

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