› 6bzs

X-ray diffraction
2.3Å resolution

Human ABCC6 NBD1 in Apo state

Released:
DOI: 10.2210/pdb6bzs/pdb
PDB entry 6bzs coloured by chain, front view.
PDB entry 6bzs coloured by chain, side view.
PDB entry 6bzs coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis reveals pathomechanisms associated with pseudoxanthoma elasticum-causing mutations in the ABCC6 transporter.
Ran Y, Zheng A, Thibodeau PH
J Biol Chem 293 15855-15866 (2018)
PMID: 30154241

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + glutathione-S-conjugate(Side 1) = ADP + phosphate + glutathione-S-conjugate(Side 2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131867 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-binding cassette sub-family C member 6 Chain: A
Molecule details ›
Chain: A
Length: 238 amino acids
Theoretical weight: 25.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95255 (Residues: 622-859; Coverage: 16%)
Gene names: ABCC6, ARA, MRP6
Sequence domains: ABC transporter
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P3221
Unit cell:
a: 94.204Å b: 94.204Å c: 46.11Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.21 0.264
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Structural and Functional Characterization of the ABCC6 Transporter in Hepatic Cells: Role on PXE, Cancer Therapy and Drug Resistance.
Bisaccia et al. (2021)
2 other articles

4 mentions without citation

Structural analysis reveals pathomechanisms associated with pseudoxanthoma elasticum-causing mutations in the ABCC6 transporter.
Ran et al. (2018)
3 more